Kir2.1

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Potassium channel, inwardly rectifying subfamily J, member 2
250px
PDB rendering based on 1u4f.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols KCNJ2 ; ATFB9; HHBIRK1; HHIRK1; IRK1; KIR2.1; LQT7; SQT3
External IDs OMIM600681 MGI104744 HomoloGene20249 IUPHAR: 430 GeneCards: KCNJ2 Gene
RNA expression pattern
File:PBB GE KCNJ2 206765 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3759 16518
Ensembl ENSG00000123700 ENSMUSG00000041695
UniProt P63252 P35561
RefSeq (mRNA) NM_000891 NM_008425
RefSeq (protein) NP_000882 NP_032451
Location (UCSC) Chr 17:
70.17 – 70.18 Mb
Chr 11:
111.07 – 111.08 Mb
PubMed search [1] [2]

The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene.[1][2][3]

Clinical significance

A defect in this gene is associated with Andersen-Tawil syndrome.[4]

A mutation in the KCNJ2 gene has also been shown to cause short QT syndrome.[5]

In research

A trafficking sequence from Kir2.1 has been added to halorhodopsin to improve its membrane localization. The resulting protein eNpHR3.0 is used in optogenetic research to inhibit neurons with light.[6]

Interactions

Kir2.1 has been shown to interact with:

References

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Further reading

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External links


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