LY-235,959

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LY-235,959
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Systematic (IUPAC) name
(3S,4aR,6S,8aR)-6-(phosphonomethyl)-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline-3-carboxylic acid
Identifiers
CAS Number 137433-06-8 YesY
PubChem CID: 131938
ChemSpider 116555
Chemical data
Formula C11H20NO5P
Molecular mass 277.11 g/mol

LY-235,959 is a competitive antagonist at the NMDA receptor.[1] It has analgesic and neuroprotective effects and causes hypothermia in animal models,[2] as well as reducing the development of tolerance to morphine and altering the reinforcing effects of cocaine.[3][4][5][6][7]

References

  1. Allen, R. M.; Dykstra, L. A. (2001). "N-methyl-D-aspartate receptor antagonists potentiate the antinociceptive effects of morphine in squirrel monkeys". The Journal of Pharmacology and Experimental Therapeutics. 298 (1): 288–297. PMID 11408554.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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