List of bus routes in Onondaga County, New York

The following bus routes operate in Onondaga County, New York. Most routes are operated from CENTRO's Onondaga County Division.

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Route	Terminals			Major streets traveled	History & notes
110, 210, 310, 410, 410X	Syracuse Centro Transit Hub	↔	South Salina Valley Fair (110, 210, and 310 trips)	110/410: South Salina Street 210 South Salina Street, Glen Avenue and Springfield Avenue 310 South Salina Street, Glen Avenue and Springfield Avenue, Valley Drive 410X South Salina Street, I-81, Adams Street	110:Runs Weekdays and Saturdays Only 210 & 310: Run weekdays only 410: Runs Daily 410X: Runs Express between Valley Fair and Upstate University Hospital, via I-81 310 Saturday Service Discontinued in 2011
		↔	Nedrow Salina Street and Conklin Avenue (410/410X trips)
16, 116, 216, 316	Syracuse Centro Transit Hub	↔	Syracuse William F. Walsh Regional Transportation Center (16 trips)	All Trips North Salina Street, North First Street 116: Buckley Road 216: Buckley Road, North Seventh Street, Electronics Parkway, Hopkins Drive 316: Buckley Road, North Seventh Street, Electronics Parkway, Old Liverpool Road, Vine Street	216 runs early mornings and weekday afternoons 316 runs late weekday evenings 316 New Route 2011
		↔	Salina Elwood Davis Road & Buckley Road (116 trips) or Electronics Parkway & Limestone Drive (216/316 trips)
20, 120	Syracuse Centro Transit Hub	↔	Lyncourt Leo Avenue and Lepage Place (20 trips)	All Trips James Street 120: Milder Avenue, New Court Avenue	120 runs rush hours only 20 runs weekday rush hours, early midday, and weekends (PM hours only) Alternative Service available on the 21, 23, 121, 80 & 180.
		↔	Lyncourt Newcourt Avenue and Swanesa Avenue (120 trips)
21,121	Syracuse Centro Transit Hub	↔	Eastwood Conklin Street and Glencove Road (21 trips)	All Trips James Street, Herbst Avenue, Glencove Road 121: Grant Blvd	21 runs Rush hours Only 121 runs middays only No Saturday or Sunday Service; alternative travel is available on the 20 and 123.
		↔	Eastwood Heights Sunnycrest Road and Midler Avenue
22,122	Syracuse Centro Transit Hub	↔	East Syracuse 5603 Brittonfield Parkway (22 trips),	All Trips James Street, Thompson Road, New Venture Gear Drive 122: Fly Road	No Sunday Service; alternative travel is only available between East Syracuse and West of Thompson Road on the 123
		↔	East Syracuse Walmart (122 trips)
23, 123	Syracuse Centro Transit Hub	↔	East Syracuse East Irving Avenue & Hartwell Avenue (23 trips)	All Trips James Street, West Manlius Street 123: Route 290, Basile Rowe	23 runs rush hours only
		↔	East Syracuse Walmart (123 trips)
223, 323, 323X	Syracuse Centro Transit Hub	↔	Dewitt Shoppingtown Mall (223 trips) or Minoa South Main Street and Hulbert Street (Select AM 223 trips)	223/323 James Street, West Manlius Street 223: Wildwaters Parkway 323: North Central Avenue 323X: Interstate 690, North Central Avenue	223 runs Weekdays only 323 runs rush hours in the peak direction 323X runs PM rush hours from Minoa to Downtown Syracuse Only No Saturday or Sunday Service; alternative travel is available only between Shoppingtown Mall and Downtown Syracuse on the 20, 123, 168, and 176
		← AM ---- → PM (323) ← PM (323X)	Minoa South Main Street and Hulbert Street (323/323X trips)
26, 126	Syracuse Centro Transit Hub	←→ AM (Weekdays Only) ---- ←→ PM (School Days and Saturdays)	Southside Corcoran High School (26 trips)	All trips West Onondaga Street, South Avenue 26: Glenwood Avenue 126: Broad Road	26 runs school days only from September to June as well as Saturday Afternoons (year-round) 126 runs AM and PM rush hours on weekdays only (does not serve Corcoran High School) 26 buses run only one trip to Downtown in the morning, and one trip to Corcoran High School in the afternoon 126 buses run only one trip to Upstate University Hospital in the morning, and one trip to Downtown in the afternoon No Evening or Sunday Service; alternative service available on the 28 and 128. Alternative Service available on the 226, 226X, and 326 during Peak Periods & Middays.
		←→ AM ---- ←→ PM	Onondaga Upstate University Hospital at Community General (126 trips)
226, 226X, 326	Syracuse Centro Transit Hub	←→	Onondaga Onondaga Community College Allyn Hall (226X trips) or Coyne Building (226 trips)	All trips West Onondaga Street, South Avenue, Onondaga Road, Seneca Tpke	226 runs additional PM trips between August and May only when OCC is in session, bypassing Van Duyn Hospital and Upstate University Hospital at Community General 226X runs during AM rush hours to OCC. The 8:45 AM 226X weekday trip also runs on Saturdays and Sundays when OCC is in session 226X trips run express from Downtown Syracuse to Velasko Road and Onondaga Road No Evening or Sunday Service; alternative service available on the 28 and 128. 326 operates 1 AM and 1 PM trip as a loop (PM loop skips Van Duyn Hospital) Some 226 trips originate at Van Duyn Hospital, enter OCC, and go along the regular 226 route, bypassing the hospitals
		↺	Onondaga High Acres (326 trips)
28, 128	Syracuse Centro Transit Hub	←→	Onondaga Onondaga Community College Allyn Hall (128 trips)	All trips West Onondaga Street, South Avenue, Valley Drive 128: West Seneca Turnpike, Onondaga Road	28 runs as a loop on Weekdays, not serving Onondaga Community College Saturday and Sunday 28 runs only from Downtown Syracuse to Van Duyn Hospital (one trip only) 128 runs weekday evenings, Saturdays, and Sundays No AM, PM, Midday, and Saturday Daytime Service; Alternative Service available on the 26, 126, 226, 254, 310, and 326 during those periods
		↺ Weekday evenings ---- → Saturday and Sunday evenings	Onondaga Van Duyn Hospital (28 trips)
36, 136	Syracuse Centro Transit Hub	←→	Fairmount Camillus Commons (36 trips)	All trips West Genesee Street	36 runs Daily, with no service running in the reverse peak direction (136 runs during those times) 136 runs Daily, with only 3 round-trips a day on Saturdays and Sundays Alternative Service available on the 236 (daily) only between Downtown Syracuse and Camillus Commons.
		←→	Camillus West Geneese Street and Maple Drive (136 trips)
236, 38, 138	Syracuse Centro Transit Hub (38 and Weekday 236 trips); Galeville William F. Walsh Regional Transportation Center (Weekend 236 trips); Syracuse Upstate University Hospital (PM reverse peak 138 trips); or Syracuse University College Place (Peak directional 138 trips)	←→	Auburn State and Wall Street	38: State Street (Syracuse), Interstate 690, NYS Route 5, NYS Route 31, NYS Route 34, Grant Avenue (Auburn) 138: State Street (Syracuse), Grand Avenue, Howlett Hill Road, Genesee Street 236: State Street (Syracuse), West Genesee Street, Howlett Hill Road, Genesee Street	138 runs to Downtown in the Morning, and in both directions in the PM rush hour 236 runs Daily, with only 3 round-trips a day on Saturdays and Sundays 236 runs to the William F. Walsh Regional Transportation Center on Weekends Alternative Service available on the 236 route between Downtown Syracuse and Camillus Commons by the 36 & 136 Alternative Service available only Between Tauton and Downtown Syracuse (138) by the 166 and 264 routes 38 runs via Jordan, Elbridge, and Weedsport 138 runs via Marcellus, Skaneateles, and Tauton 236 runs via Marcellus, Skaneateles, and Fairmount

See also

• Syracuse metropolitan area