Lu AA-33810

Lu AA-33810

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Systematic (IUPAC) name
N-[(trans-4-[(4,5-Dihydro[1]benzothiepino[5,4-d]thiazol-2-yl)amino]cyclohexyl)methyl]methanesulfonamide
Identifiers
ATC code	None
PubChem	CID: 22254068
ChemSpider	21223462
ChEMBL	CHEMBL1836317
Synonyms	Lu AA-33810
Chemical data
Formula	C19H25N3O2S3
Molecular mass	423.615 g/mol
SMILES O=S(C)(=O)NCC3CCC(CC3)Nc4sc2CCSc1ccccc1-c2n4
InChI InChI=1S/C19H25N3O2S3/c1-27(23,24)20-12-13-6-8-14(9-7-13)21-19-22-18-15-4-2-3-5-16(15)25-11-10-17(18)26-19/h2-5,13-14,20H,6-12H2,1H3,(H,21,22) Key:UWSBTSAJZMIHBL-UHFFFAOYSA-N
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Lu AA-33810 is a drug developed by Lundbeck, which acts as a potent and highly selective antagonist for the Neuropeptide Y receptor Y₅, with a Ki of 1.5nM and around 3300x selectivity over the related Y₁, Y₂ and Y₄ receptors. In animal studies it produced anorectic, antidepressant and anxiolytic effects, and further research is now being conducted into its possible medical application in the treatment of eating disorders.

References

1. REDIRECT Template:Peptide receptor modulators