Lumefantrine
From Infogalactic: the planetary knowledge core
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| Systematic (IUPAC) name | |
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2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-(4-chlorobenzylidene)-9H-fluoren-4-yl]ethanol
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| Clinical data | |
| AHFS/Drugs.com | International Drug Names |
| MedlinePlus | a609024 |
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| Identifiers | |
| CAS Number | 82186-77-4  |
| ATC code | P01BF01 (WHO) (combination with artemether) |
| PubChem | CID: 6437380 |
| DrugBank | DB06708  |
| ChemSpider | 4941944 |
| UNII | F38R0JR742 |
| KEGG | D03821 |
| ChEBI | CHEBI:156095 |
| ChEMBL | CHEMBL38827 |
| Chemical data | |
| Formula | C30H32Cl3NO |
| Molecular mass | 528.939 g/mol |
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Lumefantrine (or benflumetol) is an antimalarial drug. It is only used in combination with artemether. The term "co-artemether" is sometimes used to describe this combination.[1] Lumefantrine has a much longer half life compared to artemether and so is therefore thought to clear any residual parasites that remain after combination treatment.[2]
Lumefantrine, along with pyronaridine and naphtoquine, were synthesized in course of the Project 523 antimalaria drug research initiated in 1967; these compounds are all used in combination antimalaria therapies.[3][4][5]
References
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- ↑ http://aac.asm.org/content/56/5/2465.full
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