MT-ATP8

The 46-nucleotide overlap in the reading frames of the human mitochondrial genes MT-ATP8 and MT-ATP6. For each nucleotide triplet (square brackets), the corresponding amino acid is given (one-letter code), either in the +1 frame for MT-ATP8 (in red) or in the +3 frame for MT-ATP6 (in blue).

ATP synthase protein 8 (metazoa)
Identifiers
Symbol	ATP-synt_8
Pfam	PF00895
Pfam clan	CL0255
InterPro	IPR001421
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Plant ATP synthase F0 subunit 8
Identifiers
Symbol	YMF19
Pfam	PF02326
Pfam clan	CL0255
InterPro	IPR003319
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Fungal ATP synthase protein 8 (A6L)
Identifiers
Symbol	Fun_ATP-synt_8
Pfam	PF05933
Pfam clan	CL0255
InterPro	IPR009230
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

The protein

ATP synthase protein 8 is a subunit of mitochondrial ATP synthase.

This protein subunit appears to be an integral component of the stator stalk in yeast mitochondrial F-ATPases. The stator stalk is anchored in the membrane, and acts to prevent futile rotation of the ATPase subunits relative to the rotor during coupled ATP synthesis/hydrolysis. This subunit may have an analogous function in Metazoa.

Subunit 8 differs in sequence between Metazoa, plants and Fungi.

The gene

The ATP synthase protein 8 of human and other mammals is encoded in the mitochondrial genome by the MT-ATP8 gene. When the complete human mitochondrial genome was first published, the MT-ATP8 gene was described as the unidentified reading frame URF A6L.

An unusual feature of the MT-ATP8 gene is its 46-nucleotide overlap with the MT-ATP6 gene. With respect to the reading frame (+1) of MT-ATP8, the MT-ATP6 gene starts on the +3 reading frame.

Further reading

This article incorporates text from the public domain Pfam and InterPro IPR001421