MYBL2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.[1]
Function
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.[2]
Interactions
MYBL2 has been shown to interact with:
- CDK9,[3]
- CREB-binding protein,[4]
- Cyclin A1,[5]
- Cyclin-dependent kinase inhibitor 1C[6]
- EP300,[7]
- PARP1,[8] and
- Retinoblastoma-like protein 1.[6][9]
References
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Further reading
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External links
- MYBL2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |
