Matrine

Matrine

Systematic (IUPAC) name
(7aS,13aR,13bR,13cS)-dodecahydro-1H,5H,10H-dipyrido[2,1-f:3′,2′,1′-ij][1,6]naphthyridin-10-one
Clinical data
Legal status	Unscheduled
Identifiers
CAS Number	519-02-8 Y
ATC code	none
PubChem	CID: 91466
ChemSpider	553788 Y
ChEMBL	CHEMBL204860 N
Chemical data
Formula	C15H24N2O
Molecular mass	248.364 g/mol
SMILES C1C[C@@H]2[C@H]3CCCN4[C@H]3[C@@H](CCC4)CN2C(=O)C1
InChI InChI=1S/C15H24N2O/c18-14-7-1-6-13-12-5-3-9-16-8-2-4-11(15(12)16)10-17(13)14/h11-13,15H,1-10H2/t11-,12+,13+,15-/m1/s1 Y Key:ZSBXGIUJOOQZMP-UKTARXLSSA-N Y
NY (what is this?)  (verify)

Matrine is an alkaloid found in plants from the Sophora genus. It has a variety of pharmacological effects, including anti-cancer effects, and action as a kappa opioid receptor and µ-receptor agonist.

Matrine possesses strong antitumor activities in vitro and in vivo. Inhibition of cell proliferation and induction of apoptosis are the likely mechanisms responsible for matrine's antitumor activities. Matrine is a component of the traditional Chinese medical herb Sophora flavescens Ait.

Mu opioid agonism is associated with euphoria, while kappa opioid agonism is associated with dysphoria and psychotomimetic hallucinations (as seen in the kappa-agonist Salvinorin A). Both receptors are known to produce analgesia when activated.

Matrine and the related compound oxymatrine have an antifeedant effect against Formosan subterranean termite.