Mepiprazole

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Mepiprazole
Mepiprazole structure.svg
Systematic (IUPAC) name
1-(3-chlorophenyl)-4-[2-(5-methyl-1H-pyrazol-3-yl)ethyl]piperazine
Clinical data
Trade names Psigodal
Legal status
  • ℞ (Prescription only)
Routes of
administration		 Oral
Identifiers
CAS Number 20326-12-9
20344-15-4 (hydrochloride)
ATC code none
PubChem CID: 71897
ChemSpider 64909
UNII 977BAL0NR7 YesY
Synonyms PAP, EMD-16,923, H-4,007
Chemical data
Formula C16H21ClN4
Molecular mass 304.82 g/mol
  • Clc3cccc(N2CCN(CCc1nnc(c1)C)CC2)c3

Mepiprazole (Psigodal) is a minor tranquilizer with a phenylpiperazine structure used in Spain for the treatment of anxiety neuroses.[1][2][3][4][5] It acts as a 5-HT2A and α1-adrenergic receptor antagonist,[6][7][8] and has also been shown to inhibit the reuptake and induce the release of serotonin, dopamine, and norepinephrine to varying extents.[8][9] Controlled clinical trials of mepiprazole in patients with irritable bowel syndrome (IBS) were also carried out and suggested some benefits of the drug in relieving symptoms of IBS in some patients.[10] Similarly to other phenylpiperazines like trazodone, nefazodone, and etoperidone, mepiprazole produces mCPP as an active metabolite.[11]

See also

References

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