Mequitazine

Mequitazine

Systematic (IUPAC) name
10-(1-azabicyclo[2.2.2]octan-3-ylmethyl)phenothiazine
Clinical data
Trade names	Primalan
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	29216-28-2 Y
ATC code	R06AD07 (WHO)
PubChem	CID: 4066
DrugBank	DB01071 N
ChemSpider	3926 N
UNII	Y463242LY2 N
KEGG	D01324 Y
Chemical data
Formula	C20H22N2S
Molecular mass	322.468 g/mol
NY (what is this?)  (verify)

Mequitazine (trade name Primalan) is an antihistamine and anticholinergic of the phenothiazine chemical class. It is used to treat allergies and rhinitis.

Contraindications

Severe liver disease; premature infants or full-term neonates.

Special precautions

Pregnancy, lactation; severe cardiovascular disorders; asthma; angle-closure glaucoma, urinary retention, prostatic hyperplasia, pyloroduodenal obstruction; renal and hepatic impairment; elderly, children; epilepsy. May impair ability to drive or operate machinery.

Adverse drug reactions

CNS depression including slight drowsiness to deep sleep, lassitude, dizziness, incoordination. Headache, psychomotor impairment and antimuscarinic effects. Rarely, rashes and hypersensitivity reactions, blood disorders, convulsions, sweating, myalgia, paraesthesias, extrapyramidal effects, tremor, confusion, sleep and GI disturbances, tinnitus, hypotension, hair loss. Photosensitivity, jaundice.

Drug interactions

Enhances effects of CNS depressants e.g. alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytics and antipsychotics. Can mask signs of ototoxicity caused by aminoglycosides. QT prolongation (which can lead to torsades de pointes arrhythmia) reported with spiramycin.

See also

• Phenothiazine