Mesembrenone
From Infogalactic: the planetary knowledge core
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Names | |
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IUPAC name
(3aR,7aS)-3a-(3,4-Dimethoxyphenyl)-1-methyl-1,2,3,3a,7,7a-hexahydro-6H-indol-6-one
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Identifiers | |
468-54-2 | |
ChemSpider | 187467 |
Jmol 3D model | Interactive image |
PubChem | 216272 |
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Properties | |
C17H21NO3 | |
Molar mass | 287.36 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Mesembrenone is an alkaloid constituent of Sceletium tortuosum (Kanna). Similar to modern synthetic antidepressants, it is a potent (IC50 < 1 μM) selective inhibitor of the serotonin transporter (SERT) (that is, a selective serotonin reuptake inhibitor; Ki = 27 nM) and also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM).[1]
See also
- Mesembrine another alkaloid constituent of Kanna.
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.