Metaphit

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Metaphit
Metaphit.svg
Names
IUPAC name
1-[1-(3-isothiocyanatophenyl)cyclohexyl]piperidine
Identifiers
ChEMBL ChEMBL41541 YesY
ChemSpider 102730 YesY
Jmol 3D model Interactive image
PubChem 114745
Properties
C18H24N2S
Molar mass 300.462
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY verify (what is YesYN ?)
Infobox references
Metaphit as a methanesulfonate salt

Metaphit (1-[1-(3-Isothiocyanato)phenyl]cyclohexylpiperidine) is a research chemical that acts as an acylator of NMDARAn, sigma and DAT binding sites in the CNS. It is the m-isothiocyanate derivative of phencyclidine & binds irreversibly (forming a covalent bond) to the PCP binding site on the NMDA receptor complex.[1] However, later studies suggest the functionality of metaphit is mediated by sites not involved in PCP-induced passive avoidance deficit, and not related to the NMDA receptor complex.[2] Metaphit was also shown to prevent d-amphetamine induced hyperactivity, while significantly depleting dopamine content in the nucleus accumbens.[3] Metaphit was the first acylating ligand used to study the cocaine receptor.[4]

References

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