Methylmalonyl-CoA
From Infogalactic: the planetary knowledge core
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Names | |
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IUPAC name
(9R)-1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]-3,5,9-trihydroxy-8,8,20-trimethyl-10,14,19-trioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphahenicosan-21-oic acid 3,5-dioxide (non-preferred name)
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Identifiers | |
1264-45-5 | |
ChEBI | CHEBI:16625 |
ChemSpider | 110440 |
5223 | |
Jmol 3D model | Interactive image |
PubChem | 123909 |
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Properties | |
C25H40N7O19P3S | |
Molar mass | 867.608 g/mol |
Vapor pressure | {{{value}}} |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references | |
Methylmalonyl-CoA is the thioester consisting of coenzyme A linked to methylmalonic acid. It is an important intermediate in the biosynthesis of many organic compounds as well as in the process of carbon assimilation.[1]
Biosynthesis and conversions
Methylmalonyl-CoA is formed from propionyl-CoA by propionyl-CoA carboxylase by help of biotin (vitamin B7). It is converted into succinyl-CoA by methylmalonyl-CoA mutase, in a reaction that requires vitamin B12 as a cofactor. In this way, it enters the Krebs cycle. The following diagram demonstrates the aforementioned reactions:[2]
- Propionyl CoA → Methylmalonyl CoA → Succinyl CoA
See also
References
- ↑ Tabita, F. R., "The hydroxypropionate pathway of CO2 fixation: Fait accompli", Proceedings of the National Academy of Sciences 2009, vol. 106, 21015-21016. doi:10.1073/pnas.0912486107
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
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