Mitratapide

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Mitratapide
File:Mitratapide.svg
Systematic (IUPAC) name
2-[(2R)-Butan-2-yl]-4-[4-[4-[4-[[(2S,4R)-2-(4-chlorophenyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanylmethyl]-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
Clinical data
Trade names Yarvitan
Identifiers
CAS Number 179602-65-4
ATCvet code QA08AB90 (WHO)
PubChem CID: 213047
ChemSpider 184740
UNII FVW7T75XP4
Synonyms Mitratapid; R103757
Chemical data
Formula C36H41ClN8O4S
Molecular mass 717.28 g/mol
  • CC[C@@H](C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@@H]5CO[C@@](O5)(CSC6=NN=CN6C)C7=CC=C(C=C7)Cl
  • InChI=1S/C36H41ClN8O4S/c1-4-26(2)45-35(46)44(25-39-45)31-11-9-29(10-12-31)42-17-19-43(20-18-42)30-13-15-32(16-14-30)47-21-33-22-48-36(49-33,27-5-7-28(37)8-6-27)23-50-34-40-38-24-41(34)3/h5-16,24-26,33H,4,17-23H2,1-3H3/t26-,33-,36-/m1/s1
  • Key:HQSRVYUCBOCBLY-XOOFNSLWSA-N

Mitratapide is a veterinary drug for the treatment of overweight and obese dogs sold under the brand name Yarvitan. Its mechanism of action involves inhibition of microsomal triglyceride transfer protein (MTP) which is responsible for the absorption of dietary lipids.[1] Clinical study also suggests that mitratapide may help to reverse insulin resistance in dogs.[2]

The drug was developed by Janssen Pharmaceutica and is chemically related to the antifungal drugs such as itraconazole which were also developed by Janssen.

See also

References

  1. Mitratapide, vetstream.com
  2. Lua error in package.lua at line 80: module 'strict' not found.

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