Mofegiline

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Mofegiline
Mofegiline.svg
Systematic (IUPAC) name
(2E)-2-(fluoromethylidene)-4-(4-fluorophenyl)butan-1-amine
Clinical data
Legal status
  • Development terminated
Routes of
administration		 Oral[1]
Pharmacokinetic data
Biological half-life 1–3 hours[1]
Excretion Urine[2]
Identifiers
CAS Number 119386-96-8
ATC code None
PubChem CID: 6437850
ChemSpider 4942371
UNII 1FMJ6D8Y1B
Synonyms MDL-72,974A
Chemical data
Formula C11H13F2N
Molecular mass 197.224 g/mol
  • Fc1ccc(cc1)CCC(=[C@H]F)CN
  • InChI=1S/C11H13F2N/c12-7-10(8-14)2-1-9-3-5-11(13)6-4-9/h3-7H,1-2,8,14H2/b10-7+
  • Key:VXLBSYHAEKDUSU-JXMROGBWSA-N

Mofegiline (MDL-72,974) is a selective, irreversible inhibitor of monoamine oxidase B (MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) which was under investigation for the treatment of Parkinson's disease and Alzheimer's disease,[3][4][5][6] but was never marketed.[7]

Synthesis

Mofegiline synthesis:[8][9]

See also

References

  1. ↑ 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ I. A. McDonald, M. G. Palfreyman, EP 295604  (1988 to Merrell Dow).
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