Msh homeobox 2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Homeobox protein MSX-2 is a protein that in humans is encoded by the MSX2 gene.[1][2][3]
Function
This gene encodes a member of the muscle segment homeobox gene family. The encoded protein is a transcriptional repressor whose normal activity may establish a balance between survival and apoptosis of neural crest-derived cells required for proper craniofacial morphogenesis. The encoded protein may also have a role in promoting cell growth under certain conditions and may be an important target for the RAS signaling pathways. Mutations in this gene are associated with parietal foramina 1 and craniosynostosis type 2.[3]
Interactions
Msh homeobox 2 has been shown to interact with DLX5,[4] DLX2[4] and MSX1.[4]
References
Further reading
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External links
- GeneReviews/NCBI/UW/NIH entry on Enlarged Parietal Foramina/Cranium Bifidum
- MSX2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- MSX2 human gene location in the UCSC Genome Browser.
- MSX2 human gene details in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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