Multiple carboxylase deficiency
From Infogalactic: the planetary knowledge core
| Multiple carboxylase deficiency | |
|---|---|
| Classification and external resources | |
| Specialty | Lua error in Module:Wikidata at line 446: attempt to index field 'wikibase' (a nil value). |
| Patient UK | Multiple carboxylase deficiency |
| MeSH | D009100 |
Multiple carboxylase deficiency is a form of metabolic disorder involving failures of carboxylation enzymes.
The deficiency can be in biotinidase or holocarboxylase synthetase.[1]
These conditions respond to biotin.[2]
Forms include:
- Holocarboxylase synthetase deficiency - neonatal;
- Biotinidase deficiency - late onset;
If left untreated, the symptoms can include feeding problems, hypotonia, generalised erythematous rash with skin exfoliation and alopecia, failure to thrive, seizure, coma, developmental delay, foul smelling urine, metabolic acidosis, ketosis and hyperammonemia.
References
External links
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