Formetorex

Formetorex

Names
IUPAC name N-(1-Phenylpropan-2-yl)formamide
Other names Formetorex N-Formylamphetamine N-(alpha-Methylphenethyl)formamide
Identifiers
ChEMBL	ChEMBL1395071
ChemSpider	59055
Jmol 3D model	Interactive image
PubChem	65614
InChI InChI=1S/C10H13NO/c1-9(11-8-12)7-10-5-3-2-4-6-10/h2-6,8-9H,7H2,1H3,(H,11,12)
SMILES CC(CC1=CC=CC=C1)NC=O
Properties
Chemical formula	C10H13NO
Molar mass	163.22 g·mol−1
Vapor pressure	{{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Formetorex (INN), also known as formetamide or N-formylamphetamine, is an amphetamine described as an anorectic which does not appear to have ever been marketed.

Formetorex is also an intermediate in the production of amphetamine by the "Leuckart reaction." It is also commonly found as an impurity in clandestine labs where this synthesis method is used. Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines. The synthesis involves a non-metal reduction that is typically carried out in three steps. For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide. In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base. The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.

External links

• formetamide at the US National Library of Medicine Medical Subject Headings (MeSH)