CHRNA10

Cholinergic receptor, nicotinic, alpha 10 (neuronal)
Identifiers
Symbol	CHRNA10
External IDs	OMIM: 606372 MGI: 3609260 HomoloGene: 56886 IUPHAR: 470 ChEMBL: 2551 GeneCards: CHRNA10 Gene
Gene ontology Molecular function • acetylcholine-activated cation-selective channel activity • receptor binding • calcium channel activity • acetylcholine receptor activity • acetylcholine binding Cellular component • cytosol • acetylcholine-gated channel complex • membrane • cell junction • axon • neuron projection • perikaryon • synapse • postsynaptic membrane Biological process • signal transduction • positive regulation of cytosolic calcium ion concentration • synaptic transmission, cholinergic • neuromuscular synaptic transmission • response to nicotine • regulation of cell proliferation • regulation of membrane potential • inner ear morphogenesis • neurological system process • detection of mechanical stimulus involved in sensory perception of sound • calcium ion transmembrane transport • cation transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57053	504186
Ensembl	ENSG00000129749	ENSMUSG00000066279
UniProt	Q9GZZ6	B2RX82
RefSeq (mRNA)	NM_001303034	NM_001081424
RefSeq (protein)	NP_001289963	NP_001074893
Location (UCSC)	Chr 11: 3.67 – 3.67 Mb	Chr 7: 102.11 – 102.12 Mb
PubMed search	[1]	[2]

Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein that in humans is encoded by the CHRNA10 gene. The protein encoded by this gene is a subunit of the nicotinic acetylcholine receptor (nAchR).

This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system. Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.

External links

• CHRNA10 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)