NEU1

From Infogalactic: the planetary knowledge core
Jump to: navigation, search

<templatestyles src="Module:Infobox/styles.css"></templatestyles>

Sialidase 1 (lysosomal sialidase)
250px
C1-inhibitor
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols NEU1 ; NANH; NEU; SIAL1
External IDs OMIM608272 MGI894696 HomoloGene375 GeneCards: NEU1 Gene
EC number 3.2.1.18
RNA expression pattern
File:PBB GE SERPING1 200986 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4758 18010
Ensembl ENSG00000184494 ENSMUSG00000007038
UniProt Q99519 O35657
RefSeq (mRNA) NM_000434 NM_010893
RefSeq (protein) NP_000425 NP_035023
Location (UCSC) Chr 6:
31.83 – 31.83 Mb
Chr 17:
34.93 – 34.94 Mb
PubMed search [1] [2]

Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal neuraminidase enzyme which in humans is encoded by the NEU1 gene.[1][2]

Function

The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. In the lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to sialidosis.[1]

Clinical significance

Deficiencies in the human enzyme NEU1 leads to sialidosis, a rare lysosomal storage disease.[3] Sialidase has also been shown to enhance recovery from spinal cord contusion injury when injected in rats.[4]

Interactions

NEU1 has been shown to interact with Cathepsin A.[5]

References

  1. 1.0 1.1 Lua error in package.lua at line 80: module 'strict' not found.
  2. Lua error in package.lua at line 80: module 'strict' not found.
  3. Lua error in package.lua at line 80: module 'strict' not found.
  4. Lua error in package.lua at line 80: module 'strict' not found.
  5. Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found. * Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found. * Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.
  • Lua error in package.lua at line 80: module 'strict' not found.