NEU2

Sialidase 2 (cytosolic sialidase)
250px PDB rendering based on 1snt.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1SNT, 1SO7, 1VCU, 2F0Z, 2F10, 2F11, 2F12, 2F13, 2F24, 2F25, 2F26, 2F27, 2F28, 2F29
Identifiers
Symbols	NEU2 ; SIAL2
External IDs	OMIM: 605528 MGI: 1344417 HomoloGene: 3927 ChEMBL: 3200 GeneCards: NEU2 Gene
EC number	3.2.1.18
Gene ontology Molecular function • catalytic activity • hydrolase activity, acting on glycosyl bonds • exo-alpha-(2->3)-sialidase activity • exo-alpha-(2->6)-sialidase activity • exo-alpha-(2->8)-sialidase activity Cellular component • cytoplasm • cytosol Biological process • sphingolipid metabolic process • glycosphingolipid metabolic process • positive regulation of myotube differentiation • small molecule metabolic process • response to ethanol • positive regulation of myoblast differentiation Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE NEU2 221368 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4759	23956
Ensembl	ENSG00000115488	ENSMUSG00000079434
UniProt	Q9Y3R4	Q9JMH3
RefSeq (mRNA)	NM_005383.2	NM_001160163.1
RefSeq (protein)	NP_005374.2	NP_001153635.1
Location (UCSC)	Chr 2: 233.9 – 233.9 Mb	Chr 1: 89.41 – 89.49 Mb
PubMed search	[1]	[2]

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.