PBT2

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PBT2
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Names
IUPAC name
5,7-Dichloro-2-[(dimethylamino)methyl]quinolin-8-ol
Identifiers
ChemSpider 8191585
Jmol 3D model Interactive image
PubChem 10016012
  • InChI=1S/C12H12Cl2N2O/c1-16(2)6-7-3-4-8-9(13)5-10(14)12(17)11(8)15-7/h3-5,17H,6H2,1-2H3
    Key: YZPOQCQXOSEMAZ-UHFFFAOYSA-N
  • CN(C)CC1=NC2=C(C=C1)C(=CC(=C2O)Cl)Cl
Properties
C12H12Cl2N2O
Molar mass 271.14 g·mol−1
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

PBT2 is an experimental drug candidate. It is a second-generation 8-hydroxyquinoline analog[1] intended to be a successor to clioquinol and a potential treatment of Alzheimer's disease.[2]

Clinical trials

PBT2 was the subject of phase II clinical trials for Alzheimer's disease and Huntington's disease. The results for Alzheimer's disease failed to meet its goals,[3][4] and there is no evidence that PBT2 is of any benefit in Alzheimer's dementia.[5] The drug also missed efficacy goals for Huntington's disease.[6][7]

References

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