para-Chloromethamphetamine
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Systematic (IUPAC) name | |
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1-(4-Chlorophenyl)-N-methylpropan-2-amine
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Clinical data | |
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Identifiers | |
CAS Number | 30572-91-9 |
PubChem | CID: 3128 |
ChemSpider | 3016 |
Chemical data | |
Formula | C10H14ClN |
Molecular mass | 183.68 g·mol−1 |
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para-Chloromethamphetamine (also known as 4-Chloromethamphetamine and 4-CMA) is a stimulant that is the N-methyl derivative and prodrug of the neurotoxic drug para-Chloroamphetamine.[1][2] It has been found to decrease serotonin in rats.[3][4][5] Further investigation into the long-term effects of chloroamphetamines discovered that administration of 4-CMA caused a prolonged reduction in the levels of 5-HT and the activity of tryptophan hydroxylase in the brain one month after injection of a single dose of the drug.[6]
Another study on rats found that 4-Chloromethamphetamine was more potent at inducing conditioned taste aversion than methamphetamine.[7]
4-Chloromethamphetamine was further investigated in the 1960s along with 4-CA and it was noted that they differed from their parent amphetamine and methamphetamine substances by exhibiting only a slight central stimulant effect in both animals and humans and that they acted like antidepressants rather than stimulants.[8][9][10][11]
See also
References
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