Phyloscan
From Infogalactic: the planetary knowledge core
| Developer(s) | Wadsworth Center, New York State Department of Health |
|---|---|
| Initial release | March 14, 2005 |
| Stable release | 2.2 / January 28, 2010 |
| Platform | web service |
| Available in | English |
| Type | Bioinformatics tool |
| Website | http://ccmbweb.ccv.brown.edu/cgi-bin/phyloscanV2.pl |
Phyloscan[1][2] is a web service for DNA sequence analysis that is free and open to all users (without login requirement). For locating matches to a user-specified sequence motif for a regulatory binding site, Phyloscan provides a statistically sensitive scan of user-supplied mixed aligned and unaligned DNA sequence data. Phyloscan's strength is that it brings together
- the Staden method[3] for computing statistical significance,
- the "phylogenetic motif model" scanning functionality of the MONKEY software[4] that models evolutionary relationships among aligned sequences,
- the use of the Bailey & Gribskov method[5] for combining statistics across non-aligned sequence data, and
- the Neuwald & Green technique[6] for combining statistics across multiple binding sites found within a single gene promoter region.
References
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External links
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