Platelet alpha-granule

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Alpha granule
Details
Latin granulum alpha
Identifiers
Code TH H2.00.04.1.03005
TA Lua error in Module:Wikidata at line 744: attempt to index field 'wikibase' (a nil value).
TH {{#property:P1694}}
TE {{#property:P1693}}
FMA {{#property:P1402}}
Anatomical terminology
[[[d:Lua error in Module:Wikidata at line 863: attempt to index field 'wikibase' (a nil value).|edit on Wikidata]]]

In platelets, the term "alpha granules" is used to describe granules containing several growth factors.[1]

Contents of alpha-granules

Contents include insulin-like growth factor 1, platelet-derived growth factors, TGFβ, platelet factor 4 (which is a heparin-binding chemokine) and other clotting proteins (such as thrombospondin, fibronectin, factor V,[2] and von Willebrand factor).[3]

The alpha granules express the adhesion molecule P-selectin[4] and CD63.[5] These are transferred to the membrane after synthesis.

The other type of granules within platelets are called dense granules.

Clinical significance

A deficiency of alpha granules is known as gray platelet syndrome.

See also

References

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  2. http://www.bloodjournal.org/content/118/5/1190
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