Polyvinylpyrrolidone

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Polyvinylpyrrolidone
Polyvinylpyrrolidon.svg
Sample of polyvinyl pyrrolidone.jpg
Names
IUPAC name
1-ethenylpyrrolidin-2-one
Other names
PVP, Povidone, Copovidone

PVPP, Crospovidone, Polyvidone
PNVP
Poly[1-(2-oxo-1-pyrrolidinyl)ethylen]
1-Ethenyl-2-pyrrolidon homopolymer

1-Vinyl-2-pyrrolidinon-Polymere
Identifiers
9003-39-8 YesY
Abbreviations PVP, PVPP, NVP, PNVP
ChEMBL ChEMBL1909074 N
Jmol 3D model Interactive image
  • N1(C(CCC1)=O)[C@@H](C*)*
Properties
(C6H9NO)n
Molar mass 2.500 – 2.500.000 g·mol−1
Appearance white to light yellow, hygroscopic, amorphous powder
Density 1.2 g/cm3
Melting point 150 to 180 °C (302 to 356 °F; 423 to 453 K) (glass temperature)
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

Polyvinylpyrrolidone (PVP), also commonly called polyvidone or povidone, is a water-soluble polymer made from the monomer N-vinylpyrrolidone:[1]

Uses

Medical

PVP was used as a plasma volume expander for trauma victims after the 1950s.

It is used as a binder in many pharmaceutical tablets;[2] it simply passes through the body when taken orally. However, autopsies have found that crospovidone (PVPP) contributes to pulmonary vascular injury in substance abusers who have injected pharmaceutical tablets intended for oral consumption.[3] The long-term effects of crospovidone or povidone within the lung are unknown. PVP added to iodine forms a complex called povidone-iodine that possesses disinfectant properties.[4] This complex is used in various products like solutions, ointment, pessaries, liquid soaps and surgical scrubs. It is known under the trade names Pyodine and Betadine among a plethora of others.

It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). For this purpose, povidone iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost.[5]

Povidone is used as a lubricant in some eye drops, e.g. Bausch & Lomb's Soothe.

Technical

PVP is also used in many technical applications:

Other uses

PVP binds to polar molecules exceptionally well, owing to its polarity. This has led to its application in coatings for photo-quality ink-jet papers and transparencies, as well as in inks for inkjet printers.

PVP is also used in personal care products, such as shampoos and toothpastes, in paints, and adhesives that must be moistened, such as old-style postage stamps and envelopes. It has also been used in contact lens solutions and in steel-quenching solutions.[9][10] PVP is the basis of the early formulas for hair sprays and hair gels, and still continues to be a component of some.

As a food additive, PVP is a stabilizer and has E number E1201. PVPP (crospovidone) is E1202. It is also used in the wine industry as a fining agent for white wine or some beers. Other references[who?] state that polyvinyl pyrrolidone and its derivatives are fully from mineral synthetic origin. Therefore, its use in the production should not be a problem for vegans.

In molecular biology, PVP can be used as a blocking agent during Southern blot analysis as a component of Denhardt's buffer. It is also exceptionally good at absorbing polyphenols during DNA purification. Polyphenols are common in many plant tissues and can deactivate proteins if not removed and therefore inhibit many downstream reactions like PCR.

In microscopy, PVP is useful for making an aqueous mounting medium.[11]

Safety

The U.S. Food and Drug Administration (FDA) has approved this chemical for many uses,[12] and it is generally considered safe. However, there have been documented cases of allergic reactions to PVP/povidone, particularly regarding subcutaneous (applied under the skin) use and situations where the PVP has come in contact with autologous serum (internal blood fluids) and mucous membranes. For example, a boy having an anaphylactic response after application of PVP-Iodine for treatment of impetigo was found to be allergic to the PVP component of the solution.[13] A woman, who had previously experienced urticaria (hives) from various hair products, later found to contain PVP, had an anaphylactic response after povidone-iodine solution was applied internally. She was found to be allergic to PVP.[14] In another case, a man experiencing anaphylaxis after taking acetaminophen tablets orally was found to be allergic to PVP.[15]

Povidone is commonly used in conjunction with other chemicals. Some of these, such as iodine, are blamed for allergic responses, although testing results in some patients show no signs of allergy to the suspect chemical. Allergies attributed to these other chemicals may possibly be caused by the PVP instead.[16][17]

PVP has been widely used as stabilizer in nanoparticle synthesis[18]

Properties

PVP is soluble in water and other polar solvents. When dry it is a light flaky hygroscopic powder, readily absorbing up to 40% of its weight in atmospheric water. In solution, it has excellent wetting properties and readily forms films. This makes it good as a coating or an additive to coatings.

History

PVP was first synthesized by Walter Reppe and a patent was filed in 1939 for one of the most interesting derivatives of acetylene chemistry. PVP was initially used as a blood plasma substitute and later in a wide variety of applications in medicine, pharmacy, cosmetics and industrial production.[19][20]

Cross-linked derivatives

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Main article: Polyvinylpolypyrrolidone

See also

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ PVP-Iodine. ispcorp.com. 2004.
  5. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Chen, Tianming "Dental bleach", U.S. Patent 6,730,316, Priority date January 27, 2001
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lillie RD & Fullmer HM (1976) Histopathologic Technic and Practical Histochemistry, 4th ed. New York: McGraw-Hill, p. 411. ISBN 0-07-037862-2.
  12. ↑ Inactive Ingredients in FDA Approved Drugs. FDA/Center for Drug Evaluation and Research, Office of Generic Drugs, Division of Labeling and Program Support. Database Update Frequency: Quarterly. Data Through: January 6, 2010. Database Last Updated: January 13, 2010 – search on povidone for list of approved items
  13. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  14. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  15. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  16. ↑ Katelaris, Constance (2009). "'Iodine Allergy' label is misleading". Australian Prescriber, Vol. 32, 125–128.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  19. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  20. ↑ Lua error in package.lua at line 80: module 'strict' not found.
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