Pregnancy-associated plasma protein A

Pregnancy-associated plasma protein A, pappalysin 1
Identifiers
Symbols	PAPPA ; ASBABP2; DIPLA1; IGFBP-4ase; PAPA; PAPP-A; PAPPA1
External IDs	OMIM: 176385 MGI: 97479 HomoloGene: 31097 GeneCards: PAPPA Gene
EC number	3.4.24.79
Gene ontology Molecular function • metalloendopeptidase activity • metallopeptidase activity • zinc ion binding Cellular component • extracellular region • membrane Biological process • proteolysis • female pregnancy • cell differentiation • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5069	18491
Ensembl	ENSG00000182752	ENSMUSG00000028370
UniProt	Q13219	Q8R4K8
RefSeq (mRNA)	NM_002581	NM_021362
RefSeq (protein)	NP_002572	NP_067337
Location (UCSC)	Chr 9: 116.15 – 116.4 Mb	Chr 4: 65.12 – 65.36 Mb
PubMed search	[1]	[2]

Pappalysin-1 also known as pregnancy-associated plasma protein A is a protein that in humans is encoded by the PAPPA gene. Pappalysin-1 is used in screening tests for Down syndrome.

Function

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses (fetuses with an abnormal number of chromosomes). For example, low PAPPA may be seen in prenatal screening for Down syndrome. Low levels may alternatively predict issues with the placenta, resulting in adverse complications such as intrauterine growth restriction, preeclampsia, placental abruption, premature birth, or fetal death.

Interactions

Pregnancy-associated plasma protein A has been shown to interact with Major basic protein.

External links

• The MEROPS online database for peptidases and their inhibitors: M43.004