RTI-32
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Systematic (IUPAC) name | |
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methyl (1R,2S,3S,5S)-3-(4-methylphenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
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Identifiers | |
CAS Number | 130342-81-3 |
PubChem | CID: 125416 |
Chemical data | |
Formula | C17H23NO2 |
Molecular mass | 273.370 g/mol |
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(–)-2β-Carbomethoxy-3β-(4-tolyl)tropane (RTI-32, tolpane) is a phenyltropane-based cocaine analog that is important in the field of medicinal chemistry for performing SAR.
It has similar properties in vitro to related drugs such as RTI-31.[1]
Whereas the potency of RTI-31 has been quoted as being as high as 64 x cocaine, RTI-32 is not anything like this strong.
Compound | DAT | DA | NET | NA | SERT | 5HT | ED50 |
Troparil | 23 | 49.8 | 550 | 37.2 | 178 | 173 | 0.34 |
RTI-32 | 1.7 | 7.02 | 36 | 8.42 | 23 | 19.4 | 0.31 |
RTI-31 | 1.1 | 3.68 | 22 | 5.86 | 4.0 | 5.0 | 0.13 |
3'4'-xylyl | 0.43 | unknown | 44 | unknown | 2.42 | unknown |
Further Analogues
- 2β-Propanoyl-3β-(4-tolyl)-tropane
- RTI-151 (chlorinated equivalent (RTI-130))
- RTI-178 (chlorinated equivalent RTI-189)
- RTI-194 (RTI-)
- RTI-195 (chlorinated equivalent RTI-188)
- RTI-199 (chlorinated equivalent RTI-200)
Another good source to read is:[2]
See also
References
- ↑ Remy P, Doder M, Lees A, Turjanski N, Brooks D. Depression in Parkinson's disease: loss of dopamine and noradrenaline innervation in the limbic system. Brain. 2005 Jun;128(Pt 6):1314-22. PMID 15716302
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
2-Carboxymethyl Esters | |
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(3,4-Disubstituted Phenyl)-tropanes | |
Arylcarboxy | |
Carboxyalkyl | |
Acyl | |
β,α Stereochemistry | |
α,β Stereochemistry | |
Heterocycles: 3-Substituted-isoxazol-5-yl | |
Heterocycles: 3-Substituted-1,2,4-oxadiazole | |
N-alkyl | |
N-replaced (S,O,C) | |
Irreversible | |
Nortropanes (N-demethylated) |
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