RUNX3
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Runt-related transcription factor 3 is a protein that in humans is encoded by the RUNX3 gene.[1]
Contents
Function
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-YGYGGT-3' found in a number of enhancers and promoters,[2] and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
In melanocytic cells RUNX3 gene expression may be regulated by MITF.[4]
Knockout mouse
Runx3 null mouse gastric mucosa exhibits hyperplasia due to stimulated proliferation and suppressed apoptosis in epithelial cells, and the cells are resistant to TGF-beta stimulation.[5]
Interactions
RUNX3 has been shown to interact with TLE1.[6]
See also
References
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Further reading
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External links
- RUNX3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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