Romosozumab
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Humanized (from mouse) |
| Target | Sclerostin |
| Clinical data | |
| Legal status |
|
| Identifiers | |
| CAS Number | 909395-70-6  |
| ATC code | none |
| KEGG | D10156 |
| Chemical data | |
| Formula | C6452H9926N1714O2040S54 |
| Molecular mass | 145.9 kg/mol |
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Romosozumab (AMG 785) is a humanized monoclonal antibody that targets sclerostin for the treatment of osteoporosis.[1]
Romosozumab was originally discovered by Celltech (now owned by UCB).[2] Celltech entered in a partnership with Amgen in 2002 for the product's development.[3]
Romosozumab is of interest because of sclerostin's specificity to bone.[4] Its use has increased bone growth in preclinical trials in osteoporotic rats and monkeys.[5][6] In a Phase I study, a single dose of Romosozumab increased bone density in the hip and spine in healthy men and postmenopausal women and the drug was well tolerated.[7] In a Phase II trial, one year of Romosozumab treatment in osteoporotic women increased bone density more than bisphosphonate and teriparatide treatment; it had mild injection side effects.[8][9]
As of January 2014[update], Phase 3 clinical trials are recruiting patients.[10]
References
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Osteocyte control of bone formation via sclerostin, a novel BMP antagonist. EMBO J. 2003 Dec 1;22(23):6267-76.
- ↑ Celltech group Annual Report and Accounts 2002
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ Lua error in package.lua at line 80: module 'strict' not found.
- ↑ ClinicalTrials.gov: Romosozumab
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