SKF-77,434

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SKF-77,434
SKF77434 structure.png
Systematic (IUPAC) name
3-allyl-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
Identifiers
CAS Number 104422-04-0
PubChem CID: 1241
Chemical data
Formula C19H21NO2
Molecular mass 295.375 g/mol
  (verify)

SKF-77,434 is a drug which acts as a selective dopamine D1 receptor partial agonist, and has stimulant and anorectic effects. Unlike other D1 agonists with higher efficacy such as SKF-81,297 and 6-Br-APB, SKF-77,434 does not maintain self-administration in animal studies, and so has been researched as a potential treatment for cocaine addiction.[1][2][3][4][5][6][7]

References

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  2. Weed, M. R.; Paul, I. A.; Dwoskin, L. P.; Moore, S. E.; Woolverton, W. L. (1997). "The relationship between reinforcing effects and in vitro effects of D1 agonists in monkeys". The Journal of Pharmacology and Experimental Therapeutics. 283 (1): 29–38. PMID 9336305.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
  3. Platt, D. M.; Rowlett, J. K.; Spealman, R. D. (2000). "Dissociation of cocaine-antagonist properties and motoric effects of the D1 receptor partial agonists SKF 83959 and SKF 77434". The Journal of Pharmacology and Experimental Therapeutics. 293 (3): 1017–1026. PMID 10869406.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>
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