SKF-83,959
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(Redirected from SKF-83959)
File:SKF-83959 structure.png | |
Systematic (IUPAC) name | |
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6-chloro-7,8-dihydroxy-3-methyl-1-(3-methylphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine
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Identifiers | |
PubChem | CID: 24278699 |
ChemSpider | 10131933 ![]() |
ChEMBL | CHEMBL520992 ![]() |
Chemical data | |
Formula | C18H20ClNO2 |
Molecular mass | 317.810 g/mol |
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SKF-83,959 is a synthetic benzazepine derivative used in scientific research which acts as an agonist at the D1-D2 dopamine receptor.[1] It behaves as a full agonist at the D1 protomer and a high-affinity partial agonist at the D2 protomer. It was further shown to act as an allosteric modulator of the sigma-1 receptor.[2] SKF-83,959 is a racemate that consists of the R-(+)- and S-(−)-enantiomers MCL 202 and MCL 201, respectively. SKF-83,959 inhibits sodium channels[3] as well as delayed rectifier potassium channels.[4]
References
Further reading
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