Somatostatin receptor 2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene.[1]
Contents
Function
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.[2]
Interactions
Somatostatin receptor 2 has been shown to interact with SHANK2.[3]
Therapeutic targeting
Most pituitary adenomas express SSTR2, but other somatostatin receptors are also found.<[4] Somatostatin analogs (i.e. Octreotide, Lanreotide ) are used to stimulate this receptors, and thus to inhibit further tumor proliferation.[5]
See also
References
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Further reading
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External links
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- somatostatin receptor 2 at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
