Suloctidil

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Suloctidil
File:Suloctidil.png
Systematic (IUPAC) name
1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol
Identifiers
CAS Number 54767-75-8
ATC code C04AX19 (WHO)
PubChem CID: 5354
ChEMBL CHEMBL588119
Chemical data
Formula C20H35NOS
Molecular mass 337.563
  (verify)

Suloctidil was a sulfer-containing aminoalcohol that was brought to market in the early 1970s as a vasodilator by Continental Pharma, a Belgian company.[1]:118–121[2]

Continental was bought by Monsanto in 1984, primarily on the promise of sales of suloctidil, which was approved in Europe at the time, but not in the US.[3] However, in 1985 Monsanto halted development and withdrew the drug worldwide following reports of liver toxicity.[4]:251

References

  1. ↑ Josef Hladovec. Antithrombotic Drugs in Thrombosis Models. CRC Press, 1989 ISBN 9780849351624
  2. ↑ Roncucci R et al. Potential antilipolytic activity of suloctidil. Naturwissenschaften. 1975 Mar;62(3):141-2 PMID 1240601. Paper cites Belgian patent 739678
  3. ↑ Staff, The Pink Sheet. No vember 5 1984 Monsanto's $150 mil. Life Sciences Research Center
  4. ↑ Department of Economic and Social Affairs of the United Nations Secretariat Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals United Nations – New York, 2005


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