TRPM1

Transient receptor potential cation channel, subfamily M, member 1
Identifiers
Symbols	TRPM1 ; CSNB1C; LTRPC1; MLSN1
External IDs	OMIM: 603576 MGI: 1330305 HomoloGene: 19940 IUPHAR: 493 GeneCards: TRPM1 Gene
Gene ontology Molecular function • calcium channel activity Cellular component • intracellular • plasma membrane • integral component of plasma membrane • new growing cell tip Biological process • transport • G-protein coupled glutamate receptor signaling pathway • visual perception • ion transmembrane transport • retinal rod cell development • transmembrane transport • calcium ion transport into cytosol • calcium ion transmembrane transport • cellular response to light stimulus Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE TRPM1 206479 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4308	17364
Ensembl	ENSG00000134160	ENSMUSG00000030523
UniProt	Q7Z4N2	Q2TV84
RefSeq (mRNA)	NM_001252020	NM_001039104
RefSeq (protein)	NP_001238949	NP_001034193
Location (UCSC)	Chr 15: 31 – 31.16 Mb	Chr 7: 64.15 – 64.27 Mb
PubMed search	[1]	[2]

Transient receptor potential cation channel subfamily M member 1 is a protein that in humans is encoded by the TRPM1 gene.

Function

The protein encoded by this gene is a member of the transient receptor potential (TRP) family of non-selective cation channels. The expression of this protein is inversely correlated with melanoma aggressiveness, suggesting that it suppresses melanoma metastasis. The expression of the TRPM1 gene is regulated by the Microphthalmia-associated transcription factor.

Clinical significance

Mutations in TRPM1 are associated with congenital stationary night blindness in humans and coat spotting patterns in Appaloosa horses.

See also

• TRPM

External links

• TRPM1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.