TSHZ3

Teashirt zinc finger homeobox 3
PDB rendering based on 2dmi.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DMI
Identifiers
Symbols	TSHZ3 ; TSH3; ZNF537
External IDs	OMIM: 614119 MGI: 2442819 HomoloGene: 10835 GeneCards: TSHZ3 Gene
Gene ontology Molecular function • DNA binding • chromatin binding • protein binding • metal ion binding Cellular component • nucleus • nucleoplasm • growth cone Biological process • regulation of respiratory gaseous exchange by neurological system process • transcription, DNA-templated • multicellular organismal development • negative regulation of transcription, DNA-templated Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	57616	243931
Ensembl	ENSG00000121297	ENSMUSG00000021217
UniProt	Q63HK5	Q8CGV9
RefSeq (mRNA)	NM_020856	NM_172298
RefSeq (protein)	NP_065907	NP_758502
Location (UCSC)	Chr 19: 31.27 – 31.35 Mb	Chr 7: 36.7 – 36.77 Mb
PubMed search	[1]	[2]

Teashirt homolog 3 is a protein that in humans is encoded by the TSHZ3 gene. In mice, it is a necessary part of the neural circuitry that controls breathing. The gene is also a homolog of the Drosophila melanogaster teashirt gene, which encodes a zinc finger transcription factor important for development of the trunk.

Tshz3-knockout mice do not develop the respiratory rhythm generator (RRG) neural circuit, which is a pacemaker that produces an oscillating rhythm in the brainstem and controls autonomous breathing. The RRG neurons are present, but are abnormal. Those mice do not survive because they don't initiate breathing after birth. Tshz-3 is being studied for its relationship to infant breathing defects in humans.