Tachykinin receptor 2
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Substance-K receptor is a protein that in humans is encoded by the TACR2 gene.[1]
Contents
Function
This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A.[1]
Selective Ligands
Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an anxiolytic and antidepressant.
Agonists
- GR-64349 - potent and selective agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3
Antagonists
- Ibodutant
- Saredutant
- GR-159,897
- MEN-10376 - potent and selective antagonist, 7-amino acid polypeptide chain. CAS# 135306-85-3
See also
References
Further reading
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External links
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.
