Takeda Pharmaceutical Company

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Takeda Pharmaceutical Company Limited
Native name
 武田薬品工業株式会社
Public KK
Traded as
Industry Pharmaceuticals
Founded Doshomachi, Osaka, Japan (June 12, 1781 (1781-06-12))
Headquarters 1-1, Doshomachi Yonchome, Chuo-ku, Osaka, Japan
Key people
 Yasuchika Hasegawa
(Chairman of the Board)
Christophe Weber[1]
(President & CEO)
Revenue Increase ¥1,557,267 million (FY 2012)[* 1]
Decrease ¥122,505 million (FY 2012)[* 1]
Increase ¥131,244 million (FY 2012)[* 1]
Total assets Increase ¥3,955,599 million (FY 2012)[* 1]
Total equity Increase ¥2,223,359 million (FY 2012)[* 1]
Number of employees
 30,481 (2012)
Website takeda.com (Global website)
Footnotes / references
  1. ↑ 1.0 1.1 1.2 1.3 1.4 Lua error in package.lua at line 80: module 'strict' not found.

Takeda Pharmaceutical Company Ltd (武田薬品工業株式会社 Takeda Yakuhin Kōgyō Kabushiki-gaisha?) is the largest pharmaceutical company in Japan and Asia and a top 15 pharmaceutical company. The company has over 30,000 employees worldwide and achieved 16.2 billion USD in revenue during the 2012 fiscal year.[2] The company is focused on metabolic disorders, gastroenterology, neurology, inflammation, as well as oncology through its independent subsidiary, Millennium: The Takeda Oncology Company.[3] Its headquarters is located in Chuo-ku, Osaka, and it has an office in Nihonbashi, Chuo, Tokyo.[4][5] In January 2012, Fortune Magazine ranked the Takeda Oncology Company as one of the 100 best companies to work for in the United States.

History

Takeda Pharmaceuticals was founded on June 12, 1781 and was incorporated on January 29, 1925.

Takeda's Japanese logo

In 1977, Takeda first entered the U.S. pharmaceutical market by developing a joint venture with Abbott Laboratories called TAP Pharmaceuticals.[6] Through TAP Pharmaceuticals, Takeda and Abbott launched the blockbusters Lupron (leuprolide) in 1985 and Prevacid (lansoprazole) in 1995.

One of the firm's mainstay drugs is Actos, a compound in the thiazolidinedione class of drugs used in the treatment of type 2 diabetes. Launched in 1999, Actos has become the best-selling diabetes drug in the world with 4 billion USD in sales during the 2008 fiscal year.[7]

In February 2005, Takeda announced its acquisition of San Diego, California-based Syrrx, a company specializing in high-throughput X-ray crystallography, for 270 million USD.[8]

In February 2008, Takeda acquired the Japanese operations of Amgen and rights to a dozen of the California biotechnology company's pipeline candidates for the Japanese market.[9]

In March 2008, Takeda and Abbott Laboratories announced plans to conclude their 30-year-old joint venture, TAP Pharmaceuticals, that had over 3 billion USD in sales in its final year. The split resulted in Abbott acquiring U.S. rights to Lupron and the drug's support staff. On the other hand, Takeda received rights to Prevacid and TAP's pipeline candidates. The move also increased Takeda's headcount by 3,000 employees.[10]

In April 2008, Takeda announced that it was acquiring Millennium Pharmaceuticals of Cambridge, Massachusetts, a company specializing in cancer drug research, for 8.8 billion USD. The acquisition brought in Velcade, a drug indicated for hematological malignancies, as well as a portfolio of pipeline candidates in the oncology, inflammation, and cardiovascular therapeutic areas. Millennium now operates as an independent subsidiary, "Millennium: The Takeda Oncology Company." [11]

In May 2008, the company licensed non-exclusively the RNAi technology platform developed by Alnylam Pharmaceuticals, creating a potentially long-term partnership between the companies.[12]

On May 19, 2011, Takeda Pharmaceutical and Nycomed announced that Takeda would acquire Nycomed for € 9.6 billion. The acquisition was completed by September 30, 2011.[13]

On April 11, 2012, Takeda Pharmaceutical and URL Pharma announced that Takeda would acquire URL Pharma, then run by the founder's son Richard Roberts, for 800 million USD. The acquisition was completed by June 4, 2012.[14]

On 25 May 2012, Takeda announced the purchase of Brazilian pharmaceutical company Multilab by R$ 540 million.[15]

On 26 September 2014, Takeda announced it would team up with BioMotiv with the stated aim of identifying and developing new compounds over a five-year period, worth approximately 25 million USD.[16]

On 30 September 2014, Takeda announced its intention to expand a collaboration with MacroGenics, valued up to 1.6 billion USD. The collaboration will focus on the co-development of the preclinical autoimmune compound MGD010. MGD010 is a therapy which targets the B-cell surface proteins CD32B and CD79B, and is indicated for lupus and rheumatoid arthritis.[17]

In 2015, Takeda sold its respiratory drugs business to the Swedish-British AstraZeneca for $575 million (about £383 million), a deal that included roflumilast, a treatment for chronic obstructive pulmonary disease, and which Takeda had marketed as Daliresp in the US and Daxas in Europe. AstraZeneca had already marketed Takeda's Daliresp in the US since the first quarter of 2015 - but buying the full global rights seemed likely to 'support AstraZeneca’s core respiratory business and complement its portfolio of existing treatments', London The Daily Telegraph reported quoting the pharmaceuticals multinational. It also meant that AstraZeneca would no longer have to pay royalties to the Japanese company on its sales of the drug in the US. AstraZeneca was also to get control of other respiratory products, including Alvesco and Omnaris, brand names for the steroid ciclesonide, self-administered - as Alvesco - through an inhaler by people with asthma and - as Omnaris - sprayed up bunged-up noses.[18] About 200 Takeda employees were to transfer to AstraZeneca in the first quarter of 2016.

Locations

Takeda Midosuji Building, headquarters of Takeda Pharmaceutical Company, in Chuo-ku, Osaka, Japan

Takeda operates two primary bases in Japan in Osaka and Tokyo. Its United States subsidiary is based in Deerfield, Illinois, and all Global Operations outside of Japan and U.S. are based in Opfikon (Zurich), Switzerland. The company maintains research & development sites in Osaka and Tsukuba, Japan; San Diego and San Francisco, United States; Cambridge, United Kingdom; and Singapore.[19]

The company has manufacturing facilities in Japan, China, Indonesia, Italy, and Ireland.[20] Following the Nycomed acquisition, the Takeda manufacturing sites have been extended with facilities in Argentina, Austria, Belgium, Brazil, Denmark, Estonia, Germany, Mexico, Norway and Poland. Takeda has overseas marketing presences in the U.S., UK, France, Italy, Germany, Austria, Switzerland, Spain, China, Taiwan, Philippines, Thailand, Indonesia, and Singapore. It has recently[when?] announced its first foray into Canada, Portugal, Spain, Mexico, and Ireland.[20]

Products

Some of the key products that Takeda produces on behalf of partners include:[21]

References

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  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ "FAQ." Takeda Pharmaceutical Company. Retrieved on 2011-02-02. "Q : Where is Takeda located? A : The Head Office is located in Osaka, Japan, and the Tokyo Head Office is located in Tokyo, Japan."
  5. ↑ "Overview." Takeda Pharmaceutical Company. Retrieved on 2011-02-02. "Headquarters Head Office 1-1, Doshomachi 4-chome, Chuo-ku, Osaka 540-8645" and "Tokyo Head Office 12-10, Nihonbashi 2-chome, Chuo-ku, Tokyo 103-8668"
  6. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  7. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  8. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  9. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  10. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  11. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  12. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  13. ↑ http://www.takeda.com/press/article_43116.html
  14. ↑ https://www.takeda.com/news/2012/20120605_3968.html
  15. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  16. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  17. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  18. ↑ AstraZeneca to buy Takeda's lung business for £383m, Julia Bradshaw, The Daily Telegraph, 16 December 2015.Accessed: 17 December 2015.
  19. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  20. ↑ 20.0 20.1 Lua error in package.lua at line 80: module 'strict' not found.
  21. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  22. ↑ Lua error in package.lua at line 80: module 'strict' not found.

External links

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