6-APT

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6-APT
Tetralinylaminopropane.svg
Systematic (IUPAC) name
1-(5,6,7,8-tetrahydronaphthalen-2-yl)propan-2-amine
or
1-(6-tetralinyl)propan-2-amine
Clinical data
Legal status
Routes of
administration
Oral
Identifiers
CAS Number ?
ATC code none
PubChem CID: 14964398
ChemSpider 23204045 YesY
ChEMBL CHEMBL331488
Chemical data
Formula C13H19N
Molecular mass 189.30 g/mol
  (verify)

6-(2-Aminopropyl)tetralin (6-APT), also sometimes called tetralinylaminopropane (TAP), is a drug of the amphetamine class which acts as a selective serotonin releasing agent (SSRA).[1] It has IC50 values of 121 nM, 6,436 nM, and 3,371 nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine, respectively.[1] Though it possesses an appreciable in vitro profile, in animal drug discrimination studies it was not found to substitute for MMAI or amphetamine and to only partially substitute for MBDB.[1] This parallels Alexander Shulgin's finding that EDMA (the 1,4-benzodioxine analogue of 6-APT) is inactive,[2] and appears to indicate that the pharmacokinetics of both EDMA and 6-APT may not be favorable.[1]

See also

References

  1. 1.0 1.1 1.2 1.3 Lua error in Module:Citation/CS1/Identifiers at line 47: attempt to index field 'wikibase' (a nil value).
  2. Ann Shulgin; Alexander Shulgin (1991). Pihkal: A Chemical Love Story. Transform Press. ISBN 0-9630096-0-5.<templatestyles src="Module:Citation/CS1/styles.css"></templatestyles>