Tonazocine
Systematic (IUPAC) name | |
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1-[(2S,6R,11S)-8-hydroxy-3,6,11-trimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-11-yl]octan-3-one
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Clinical data | |
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Identifiers | |
CAS Number | 71461-18-2 |
ATC code | None |
PubChem | CID: 72177 |
ChemSpider | 65150 |
UNII | J356A16LLK |
Chemical data | |
Formula | C23H35NO2 |
Molecular mass | 357.530 g/mol |
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Tonazocine (WIN-42,156) is an opioid analgesic of the benzomorphan family which made it to phase II clinical trials for the treatment of postoperative pain,[1] but development was apparently ceased and ultimately it was never marketed. Tonazocine is a partial agonist at both the mu-opioid and delta-opioid receptors, but acting more like an antagonist at the former and more like an agonist at the latter.[2][3] It lacks most of the side effects of other opioids such as adverse effects on the cardiovascular system and respiratory depression, but it can cause sedation (although to a lesser degree of typical opioids), and in some patients it may induce hallucinations (probably via binding to and activating the κ-opioid receptor).[4]
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See also: Template:Peptide receptor modulators
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- Analgesics
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