Trimethylamine N-oxide reductase
Trimethylamine N-oxide reductase (TOR or TMAO reductase, EC 1.7.2.3) is a microbial enzyme that can reduce trimethylamine N-oxide (TMAO) into trimethylamine (TMA), as part of the electron transport chain. The enzyme has been purified from E. coli and the photosynthetic bacteria Roseobacter denitrificans.[1] Both the R. denitrificans and E. coli enzymes can accept electrons from cytochromes.[2]
trimethylamine + 2 (ferricytochrome c)-subunit + H2O → trimethylamine N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+
Trimethylamine oxide is found at high concentrations in the tissues of fish, and the bacterial reduction of this compound to foul-smelling trimethylamine is a major process in the spoilage of fish.[3]
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