Trimetrexate

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Trimetrexate
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Systematic (IUPAC) name
5-methyl-6-[(3,4,5-trimethoxyphenyl) aminomethyl] quinazoline-2,4-diamine
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a694019
Pharmacokinetic data
Bioavailability VD: 20-30 Liters
Metabolism Oxidative O-demethylation, followed by conjugation with glucuronide or sulfate
Biological half-life 11 to 12 hours
Identifiers
CAS Number 52128-35-5 YesY
ATC code P01AX07 (WHO)
PubChem CID: 5583
IUPHAR/BPS 7613
DrugBank DB01157 YesY
ChemSpider 5381 YesY
UNII UPN4ITI8T4 YesY
KEGG D06238 YesY
ChEMBL CHEMBL119 YesY
Chemical data
Formula C19H23N5O3
Molecular mass 369.418 g/mol
  • n3c1c(c(c(cc1)CNc2cc(OC)c(OC)c(OC)c2)C)c(nc3N)N
  • InChI=1S/C19H23N5O3/c1-10-11(5-6-13-16(10)18(20)24-19(21)23-13)9-22-12-7-14(25-2)17(27-4)15(8-12)26-3/h5-8,22H,9H2,1-4H3,(H4,20,21,23,24) YesY
  • Key:NOYPYLRCIDNJJB-UHFFFAOYSA-N YesY
  (verify)

Trimetrexate is a quinazoline derivative. It is a dihydrofolate reductase inhibitor.[1]

Uses

It has been used with leucovorin in treating pneumocystis pneumonia.[2]

It has been investigated for use in treating leiomyosarcoma.[3] It is a methotrexate (MTX) analog that is active against transport-deficient MTX-resistant tumor cells that overcome the acquired and natural resistance to methotrexate. Other uses include skin lymphoma. [4]

References

  1. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  4. ↑ Trimetrexate in relapsed T-cell lymphoma with skin involvement. J Clin Oncol. 2002 Jun 15;20(12):2876-80.

External links



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