U12 minor spliceosomal RNA
From Infogalactic: the planetary knowledge core
U12 minor spliceosomal RNA | |
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Predicted secondary structure and sequence conservation of U12 | |
Identifiers | |
Symbol | U12 |
Rfam | RF00007 |
Other data | |
RNA type | Gene; snRNA; splicing |
Domain(s) | Eukaryota |
GO | 0000371 0045131 0005693 |
SO | 0000399 |
U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1] The predicted secondary structure of U12 RNA is published,[2] but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.[3] The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database.
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