Unifiram

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Unifiram
Unifiram.svg
Systematic (IUPAC) name
2-[(4-Fluorophenyl)sulfonyl]hexahydropyrrolo[1,2-a]pyrazin-6(2H)-one
Clinical data
Legal status
  • Unscheduled
Identifiers
CAS Number 272786-64-8 YesY
PubChem CID: 9861054
ChemSpider 8036753 N
ChEMBL CHEMBL140717 N
Chemical data
Formula C13H15FN2O3S
Molecular mass 298.333 g/mol
  • C2CN1C(=O)CCC1CN2S(=O)(=O)c(cc3)ccc3F
  • InChI=1S/C13H15FN2O3S/c14-10-1-4-12(5-2-10)20(18,19)15-7-8-16-11(9-15)3-6-13(16)17/h1-2,4-5,11H,3,6-9H2 N
  • Key:SNRTZFZAFBIBJP-UHFFFAOYSA-N N
 NYesY (what is this?)  (verify)

Unifiram (DM-232) is an ampakine-like drug derived from biarylpropylsulfonamide,[1] and has antiamnesic and other effects in animal studies with up to a thousand times higher potency than piracetam.[2][3] A number of related compounds are known, including sunifiram (DM-235).[4][5][6] Unifiram has two enantiomers, with (R)-(+)-unifiram (dextrounifiram) being the more active isomer.[7] Unifiram is shown to reduce the duration of hypnosis induced by pentobarbital, without impairing motor coordination.[8]

(R)-(+)-unifiram (dextrounifiram).
(R)-(+)-unifiram (dextrounifiram).

Safety

As of 2014, no formal human studies with unifiram have been conducted.

References

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