VUF-5681

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VUF-5681
VUF-5681.png
Names
IUPAC name
4-[3-(1H-Imidazol-4-yl)propyl]piperidine
Identifiers
768358-61-8 YesY
ChemSpider 8505701 N
Jmol 3D model Interactive image
PubChem 10330240
  • InChI=1S/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14) N
    Key: YPGRNKJNOSUCLY-UHFFFAOYSA-N N
  • InChI=1/C11H19N3/c1(3-11-8-13-9-14-11)2-10-4-6-12-7-5-10/h8-10,12H,1-7H2,(H,13,14)
    Key: YPGRNKJNOSUCLY-UHFFFAOYAZ
  • C2CNCCC2CCCc1ncnc1
Properties
C11H19N3
Molar mass 193.288
Vapor pressure {{{value}}}
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is YesYN ?)
Infobox references

VUF-5681 is a potent and selective histamine antagonist which binds selectively to the H3 subtype.[1] However while VUF-5681 blocks the activity of more potent H3 agonists, recent studies suggest that it may have some weak partial agonist activity when administered by itself.[2]

References

  1. Moreno-Delgado D, Torrent A, Gómez-Ramírez J, de Esch I, Blanco I, Ortiz J. Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology. 2006 Sep;51(3):517-23. PMID 16769092
  2. Lua error in package.lua at line 80: module 'strict' not found.


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