WAY-181,187

WAY-181,187

Systematic (IUPAC) name
2-(1-{6-chloroimidazo[2,1-b][1,3]thiazole-5-sulfonyl}-1H-indol-3-yl)ethan-1-amine
Identifiers
CAS Number	?
ATC code	none
PubChem	CID: 10150497
IUPHAR/BPS	3240
ChemSpider	8326005
ChEMBL	CHEMBL392760 Y
Chemical data
Formula	C15H13ClN4O2S2
Molecular mass	380.872 g/mol
SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
InChI InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2 Key:RYBOXBBYCVOYNO-UHFFFAOYSA-N

WAY-181,187 is a high affinity and selective 5-HT₆ receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex, hippocampus, striatum, and amygdala of rats without affecting concentrations in the nucleus accumbens or thalamus, and has modest to no effects on norepinephrine, serotonin, dopamine, or glutamate levels in these areas. WAY-181,187 has demonstrated preclinical efficacy in rodent models of depression, anxiety, and notably obsessive-compulsive disorder, though it has also been shown to impair cognition and memory.

See also

• WAY-208,466