Tu Youyou

Tu Youyou 屠呦呦
Tu Youyou, Nobel Laureate in medicine in Stockholm December 2015
Native name	屠呦呦 (Tú Yōuyōu)
Born	(1930-12-30) 30 December 1930 Ningbo, Zhejiang, China
Residence	Beijing
Citizenship	People's Republic of China
Nationality	Chinese
Fields	Medicinal chemistry Chinese herbology Antimalarial medication Clinical research
Institutions	China Academy of Traditional Chinese Medicine
Alma mater	Peking University Medical School / Beijing Medical College (now Peking University Health Science Center)
Academic advisors	Lou Zhicen (at Peking University Medical School / Beijing Medical College)
Known for	Discovering artemisinin and dihydroartemisinin in Project 523
Influences	Lou Zhicen (pharmacognosy) Ge Hong (Chinese herbology) Mao Zedong (promoting integrated traditional Chinese and modern Western medicine; ordering Project 523)
Influenced	Project 523
Notable awards	Lasker-DeBakey Clinical Medical Research Award (2011) Warren Alpert Foundation Prize (2015) Nobel Prize in Physiology or Medicine (2015)

This is a Chinese name; the family name is Tu (屠).

Tu Youyou
Chinese	屠呦呦
Literal meaning	屠 (Tú, surname) 呦 (yōu): (the sound of) deer bleating See details...
Transcriptions Standard Mandarin Hanyu Pinyin Tú Yōuyōu Wade–Giles T'u2 Yu1-yu1 IPA [tʰǔ i̯óu̯.i̯óu̯] Wu Romanization Du1 Ieu1 Ieu1

Tu Youyou (Chinese: 屠呦呦; born 30 December 1930) is a Chinese pharmaceutical chemist and educator. She is best known for discovering artemisinin (also known as qinghaosu) and dihydroartemisinin, used to treat malaria, which saved millions of lives. Her discovery of artemisinin and its treatment of malaria is regarded as a significant breakthrough of tropical medicine in the 20th century and health improvement for people of tropical developing countries in South Asia, Africa, and South America. For her work, Tu received the 2011 Lasker Award in clinical medicine and the 2015 Nobel Prize in Physiology or Medicine jointly with William C. Campbell and Satoshi Ōmura. Tu is the first Chinese Nobel laureate in physiology or medicine and the first citizen of the People's Republic of China to receive the Nobel Prize in natural sciences, as well as the first Chinese person to receive the Lasker Award. She was born and educated and carried out research exclusively in China.

Background

Tu carried on her work in the 1960s and 70s during China's Cultural Revolution, when scientists were denigrated as one of the nine black categories in society according to Maoist theory (or possibly that of the Gang of Four).

In 1967, during the Vietnam War, Ho Chi Minh, the leader of North Vietnam, which was at war against South Vietnam and the United States, asked Chinese Premier Zhou Enlai for help in developing a malaria treatment for his soldiers trooping down the Ho Chi Minh trail, where a majority came down with a form of malaria which is resistant to chloroquine. Because malaria was also a major cause of death in China's southern provinces including Hainan, Yunnan, Guangxi, and Guangdong, Zhou Enlai convinced Mao Zedong to set up a secret drug discovery project, named Project 523 after its starting date, 23 May 1967. Upon joining the project unit, Tu was initially sent to Hainan where she studied patients who had been infected with the disease. During the time she spent there, her husband was banished to the countryside, meaning that her daughter had to be entrusted to a nursery in Beijing.

Scientists worldwide had screened over 240,000 compounds without success. In 1969, Tu, then 39 years old, had an idea of screening Chinese herbs. She first investigated the Chinese medical classics in history, visiting practitioners of traditional Chinese medicine all over the country on her own. She gathered her findings in a notebook called A Collection of Single Practical Prescriptions for Anti-Malaria. Her notebook summarized 640 prescriptions. Her team also screened over 2,000 traditional Chinese recipes and made 380 herbal extracts, which were tested on mice.

One compound was effective, sweet wormwood (Artemisia annua), which was used for "intermittent fevers," a hallmark of malaria. As Tu also presented at the project seminar, its preparation was described in a 1,600-year-old text, in a recipe titled, "Emergency Prescriptions Kept Up One's Sleeve". At first, it didn't work, because they extracted it with traditional boiling water. Tu Youyou discovered that a low-temperature extraction process could be used to isolate an effective antimalarial substance from the plant; Tu says she was influenced by a traditional Chinese herbal medicine source, The Handbook of Prescriptions for Emergency Treatments, written in 340 by Ge Hong, which states that this herb should be steeped in cold water. This book contained the useful reference to the herb: "A handful of qinghao immersed with two litres of water, wring out the juice and drink it all." After rereading the recipe, Tu realised the hot water had already damaged the active ingredient in the plant; therefore she proposed a method using low-temperature ether to extract the effective compound instead. The animal tests showed it was completely effective in mice and monkeys.

Furthermore, Tu volunteered to be the first human subject. "As head of this research group, I had the responsibility" she said. It was safe, so she conducted successful clinical trials with human patients. Her work was published anonymously in 1977. In 1981, she presented the findings relating to artemisinin at a meeting with the World Health Organization.

Biography

Tu Youyou (right) and her teacher Lou Zhicen (left) in 1951

Tu was born in Ningbo, Zhejiang, China on 30 December 1930. She attended Xiaoshi Middle School for junior high school and the first year of high school, before transferring to Ningbo Middle School in 1948. From 1951 to 1955, she attended Peking University Medical School / Beijing Medical College. Tu studied at the Department of Pharmaceutical Sciences, and graduated in 1955. Later Tu was trained for two and a half years in traditional Chinese medicine.

After graduation, Tu worked at the Academy of Traditional Chinese Medicine (now the China Academy of Traditional Chinese Medical Sciences) in Beijing. She was promoted to a Researcher (研究员, the highest researcher rank in mainland China equivalent to the academic rank of a full professor) in 1980 shortly after the Chinese economic reform began in 1978. In 2001 she was promoted to academic advisor for doctoral candidates. Currently she is the Chief Scientist in the Academy.

As of 2007, her office is in an old apartment building in Dongcheng District, Beijing.

Before 2011, Tu had been obscure for decades, and is described as "almost completely forgotten by people".

Tu is regarded as the Professor of Three Noes – no postgraduate degree (there was no postgraduate education then in China), no study or research experience abroad, and not a member of any Chinese national academies, i.e. Chinese Academy of Sciences and Chinese Academy of Engineering. Up until 1979, there were no postgraduate degree programs in China, and China was largely isolated from the rest of the world. Tu is now regarded as a representative figure of the first generation of Chinese medical workers since the establishment of the People's Republic of China in 1949.

Family

Tu and her husband, Li Tingzhao (李廷钊), a metallurgical engineer, live in Beijing. Li Tingzhao was Tu's classmate at Xiaoshi Middle School. Her younger daughter lives in Beijing, seen in a few pictures. Her older daughter lives in the United States, along with her husband and daughter, seen in a few pictures (Tu Youyou's son in law and granddaughter). Tu's maternal grandfather, Yao Yongbai (姚咏白), was the first Director of National Treasury Administration after its reform. Her uncle, Yao Qingsan (姚庆三), was an eminent economist, banker, and the first Keynesian in China.

Name

See also: Classic of Poetry and Artemisia (genus)

My [first] name, Youyou, was given by my father, who adapted it from the sentence ‘呦呦鹿鸣, 食野之蒿’ translated as ‘Deer bleat “youyou” while they are eating the wild Hao’ in the Chinese Book of Odes. How this links my whole life with qinghao will probably remain an interesting coincidence forever.

— Tu Youyou, when interviewed in 2011 after awarded the 2011 Lasker-DeBakey Clinical Medical Research Award

Research

Schistosomiasis

During her early years, Tu studied Lobelia chinensis, a traditional Chinese medicine, for curing schistosomiasis, caused by parasitic worms which infect the urinary tract or the intestines, which was widespread in the first half of the 20th century in South China.

Malaria

Further information: Project 523, artemisinin, and dihydroartemisinin

Tu started her malaria research in China when the Cultural Revolution was in progress. In early 1969, Tu was appointed head of the project, named Project 523 research group at her institute. She collected 2000 candidate recipes, ancient texts, and folk remedies for possible leads for her research. By 1971, her team had made 380 extracts from 200 herbs, and discovered the extracts from qinghao (Artemisia annua, sweet wormwood) looked particularly promising in dramatically inhibiting Plasmodium growth in animals. Tu found the way to extract it and her innovations boosted potency and slashed toxicity of this extract. In 1972, she and her colleagues obtained the pure substance and named it qinghaosu (青蒿素), or artemisinin as it is commonly called in the west, which has saved millions of lives, especially in the developing world. Tu also studied the chemical structure and pharmacology of artemisinin. Tu's group first determined the chemical structure of artemisinin. In 1973, Tu wanted to confirm the carbonyl group in the artemisinin molecule, therefore she accidentally synthesized dihydroartemisinin. For her work, she was awarded the Nobel Prize in Medicine on 5 October 2015.

Awards

• 1978, National Science Congress Prize, P.R. China
• 1979, National Inventor's Prize, P.R. China
• 1992, (One of the) Ten Science and Technology Achievements in China, State Science Commission, P.R. China
• 1997, (One of the) Ten Great Public Health Achievements in New China, P.R. China
• September 2011, GlaxoSmithKline Outstanding Achievement Award in Life Science
• September 2011, Lasker-DeBakey Clinical Medical Research Award
• November 2011, Outstanding Contribution Award, China Academy of Chinese Medical Sciences
• February 2012, (One of the Ten) National Outstanding Females, P.R. China
• June 2015, Warren Alpert Foundation Prize (co-recipient)
• October 2015, Nobel Prize in Physiology or Medicine 2015 (co-recipient) for her discoveries concerning a novel therapy against Malaria, awarded with one half of this prize; and William C. Campbell and Satoshi Ōmura jointly awarded with another half for their discoveries concerning a novel therapy against infections caused by roundworm parasites.

See also

• Drug discovery
• Malaria, quinine and tropical medicine
• Antimalarial medications resulted from Project 523 (during and after the Cultural Revolution)
  • Artemisinin (major contributors: Tu Youyou, et al., 1972)
  • Dihydroartemisinin (Tu Youyou et al., 1973)
  • Pyronaridine (1973)
  • Artemether (Zhou Weishan (周维善), 1975)
  • Lumefantrine (1976)
  • Artesunate (Li Guoqiao (李国桥), 1977)
  • Artemether/lumefantrine (Zhou Yiqing (周义清), 1985)
  • Naphthoquinone (1986)
• History of science and technology in the People's Republic of China
  • First artificial synthesis of (crystallized bovine) insulin (Niu Jingyi et al., 1965)
  • Discovery of using arsenic trioxide and tretinoin to treat leukemia (Zhang Tingdong, Wang Zhenyi, Chen Zhu & Chen Saijuan)
  • Dr Tang Feifan (汤飞凡), discoverer of Chlamydia trachomatis, was expected to receive a Nobel Prize but died from political persecution in Beijing, 1958
  • Dr Wu Lien-teh, first Chinese nominated to receive a Nobel Prize in Physiology or Medicine in 1935
• List of Chinese Nobel laureates and List of female Nobel laureates
• List of Chinese discoveries and List of Chinese inventions
• Chinese herbology and Traditional Chinese medicine

External links

• Tu Youyou Quotes With Pictures