3-dehydrosphinganine reductase

3-dehydrosphinganine reductase
Identifiers
EC number	1.1.1.102
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

3-ketodihydrosphingosine reductase
Identifiers
Symbols	KDSR ; DHSR; FVT1; SDR35C1
External IDs	OMIM: 136440 MGI: 1918000 HomoloGene: 1539 GeneCards: KDSR Gene
EC number	1.1.1.102
Gene ontology Molecular function • 3-dehydrosphinganine reductase activity Cellular component • extracellular space • endoplasmic reticulum • endoplasmic reticulum membrane • membrane • integral component of membrane Biological process • sphingolipid metabolic process • 3-keto-sphinganine metabolic process • sphingolipid biosynthetic process • small molecule metabolic process • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE FVT1 202419 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2531	70750
Ensembl	ENSG00000119537	ENSMUSG00000009905
UniProt	Q06136	Q6GV12
RefSeq (mRNA)	NM_002035	NM_027534
RefSeq (protein)	NP_002026	NP_081810
Location (UCSC)	Chr 18: 63.33 – 63.37 Mb	Chr 1: 106.72 – 106.76 Mb
PubMed search	[1]	[2]

3-dehydrosphinganine reductase (EC 1.1.1.102) also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an enzyme that in humans is encoded by the KDSR gene.

Function

3-dehydrosphinganine reductase catalyzes the chemical reaction:

sphinganine + NADP⁺ $\rightleftharpoons$ 3-dehydrosphinganine + NADPH + H⁺

Thus, the two substrates of this enzyme are sphinganine and NADP⁺, whereas its 3 products are 3-dehydrosphinganine, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. This enzyme participates in sphingolipid metabolism.

Tissue distribution

Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.

Clinical significance

FVT1 shows a high rate of transcription in some T cell malignancies and in phytohemagglutinin-stimulated lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.