Aminodeoxychorismate lyase
From Infogalactic: the planetary knowledge core
| 4-amino-4-deoxychorismate lyase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.3.38 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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4-amino-4-deoxychorismate lyase (EC 4.1.3.38) is an enzyme that participates in folate biosynthesis by catalyzing the production of PABA by the following reaction
- 4-amino-4-deoxychorismate
4-aminobenzoate + pyruvate
This enzyme has one substrate, 4-amino-4-deoxychorismate, and two products, 4-aminobenzoate (PABA) and pyruvate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. This enzyme, encoded by the pabC gene in bacteria and plants, is also known as PabC or ADC lyase. The fungal enzyme has been designated ABZ2.
All known examples of 4-amino-4-deoxychorismate lyase bind PLP (pyridoxal-5'-phosphate), a cofactor employed during catalysis.
References
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