Aplaviroc
From Infogalactic: the planetary knowledge core
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Systematic (IUPAC) name | |
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4-(4-{[(3R)-1-butyl-3-[(R)-cyclohexylhydroxymethyl]-2,5-dioxo- 1,4,9-triazaspiro[5.5]undecan-9-yl]methyl}phenoxy)benzoic acid
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Clinical data | |
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Oral |
Identifiers | |
CAS Number | 461023-63-2 |
ATC code | none |
PubChem | CID: 3001322 |
IUPHAR/BPS | 805 |
ChemSpider | 2272720 |
UNII | 98B425P30V |
KEGG | D06557 |
ChEMBL | CHEMBL1255794 |
Chemical data | |
Formula | C33H43N3O6 |
Molecular mass | 577.711 g/mol |
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Aplaviroc (INN, codenamed AK602 and GSK-873140) is a CCR5 entry inhibitor developed for the treatment of HIV infection.[1][2] It was developed by GlaxoSmithKline.
In October 2005, all studies of aplaviroc were discontinued due to liver toxicity concerns.[3][4] Some authors have claimed that evidence of poor efficacy may have contributed to termination of the drug's development;[5] the ASCENT study, one of the discontinued trials, showed aplaviroc to be under-effective in many patients even at high concentrations.[6]
See also
References
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Further reading
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Categories:
- Articles with dead external links from October 2010
- Pages with broken file links
- Chemical articles having calculated molecular weight overwritten
- Infobox drug articles without a structure image
- Chemical pages without DrugBank identifier
- Drugs not assigned an ATC code
- Abandoned drugs
- Alcohols
- Benzoic acids
- Diketopiperazines
- Entry inhibitors
- Ethers
- Spiro compounds
- Antiinfective agent stubs